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ABBREVIATIONS

AAV

Adeno-associated virus

ADME

Adsorption, distribution, metabolism, and excretion

AdV

Adenovirus

AFM

Animal component free medium

amn

Ammonia

BEI

Binary ethyleneimine

BHK

Baby hamster kidney

BSL

Biosafety level

cc

Cell cube

C1

Chromatography step 1

C2

Chromatography step 2

CDM

Chemically defined medium

CEF

Chicken embryo fibroblast

CFD

Computational fluid dynamics

CFF

Cross-flow filtration

CHO

Chinese hamster ovary

CMC

Chemistry, manufacturing and controls

CRISPR/Cas

Clustered regularly interspaced short palindromic repeats

CRO

Contract research organization

CTA

Clinical trial application

DEAE

Diethylethanolamine

DF

Depth filtration

DIP

Defective interfering particle

DMSO

Dimethyl sulfoxide

DNA

Deoxyribonucleic acid

DoE

Design of experiments

DSP

Downstream processing

ECGF

Endothelial cell growth factor

EGF

Epidermal growth factor

EMA

European Medicines Agency

EP

European Pharmacopeia

FBS

Fetal bovine serum

FCS

Fetal calf serum

FDA

Food and Drug Administration

Fn

Fibronectin

GCP

Good clinical practice

Upstream processing for viral vaccines

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